Associate Scientist

Description

Johnson & Johnson Innovative Medicine is recruiting for an Associate Scientist, Parallel Medicinal Chemistry, Global Discovery Chemistry, for our site in Toledo, Spain.

At the Johnson & Johnson Innovative Medicine, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time.

And we pursue the most promising science, wherever it might be found.

We are Johnson & Johnson. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.

Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.

Global Discovery Chemistry delivers high quality drug candidates in partnership with all Johnson & Johnson Therapeutic Area (TA) discovery teams.

The successful candidate will join a team consisting of chemists with a diversity of skills including Medicinal Chemistry, Computational Chemistry and Cheminformatics, Discovery Process Research, and Analytical Chemistry.

They will leverage state-of-the art techniques and instrumentation to develop innovative strategies to design and synthesize drug candidates to advance drug discovery projects across a range of modalities, with a focus on small molecules.

Acceleration of discovery programs through application of parallel medicinal chemistry, high throughput experimentation, and reaction automation will be a focus.

The individual in this position will find significant leadership opportunity in driving the execution of these strategies, in coordination with Johnson & Johnson colleagues using innovative synthetic chemistry and building new technologies.

In addition, the successful candidate will leverage close interactions with biologists, pharmacologists, and pharmaceutical development scientists.

Strong collaboration skills and the ability to thrive in a team environment are key attributes. This individual must also excel in communication and have strong interpersonal skills necessary to influence in a fast-paced, multidisciplinary environment.

Responsibilities of the Associate Scientist include :

• Maintaining a high level of productivity in the laboratory setting.
• Independently develop synthetic strategies towards the synthesis of structurally complex drug candidates
• Independently execute synthetic route development in the laboratory, including experimentation with novel chemical reactions, solving synthetic problems through experimentation, and management of intermediates to support preparation of gram-scale quantities.
• Independently generate and interpret analytical data to monitor chemical reactions, using state-of-the art methods including TLC, LCMS, and NMR
• Adapt synthetic routes for preparation of libraries (24-96 members) including assessment of reaction robustness and generality
• Adapt routes to execute synthesis using a range of automation and instrumentation, to accelerate reaction setup, workup, and purification
• Synthesizing drug-like molecules utilizing medicinal chemistry knowledge and an understanding of ADME, pharmacokinetics and optimal physicochemical properties.
• In collaboration with Computational Chemistry colleagues, leverage a range of cutting-edge prediction tools, including artificial intelligence, machine learning, and 3D structure-based methods to enhance drug candidate design.
• Actively and independently communicate data and project status updates through a variety of channels including in-person meetings, virtual meetings, and virtual team communication channels.
• Author data reports to support patent filings and publication of peer-reviewed journal articles

Qualifications

• Bachelor's Degree in Chemistry with 2 or more years of synthetic organic or medicinal chemistry industry experience
• Master's Degree in synthetic organic chemistry with significant synthetic experience
• Strong track record of achievement in organic synthesis, with a deep knowledge of modern synthetic and analytical techniques
• Proven track record of scientific contributions including peer reviewed publications, patents and presentations is desireable but not required.
• Independent thinking and the ability to effectively collaborate in a highly matrixed environment.
• Excellent oral and written communication skills, including preparation of presentations.

Prior experience with library synthesis is desirable but not required

Prior experience with lab automation is desirable but not required

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.